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Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity
Two types of RNA:DNA associations can lead to genome instability: the formation of R-loops during transcription and the incorporation of ribonucleotide monophosphates (rNMPs) into DNA during replication. Both ribonuclease (RNase) H1 and RNase H2 degrade the RNA component of R-loops, whereas only RNa...
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| Publicado en: | Genetics |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Genetics Society of America
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4649664/ https://ncbi.nlm.nih.gov/pubmed/26400613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.182725 |
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