Caspase-9 mediates Puma activation in UCN-01-induced apoptosis

The protein kinase inhibitor 7-hydroxystaurosporine (UCN-01) is one of the most potent and frequently used proapoptotic stimuli. The BH3-only molecule of Bcl-2 family proteins has been reported to contribute to UCN-01-induced apoptosis. Here we have found that UCN-01 triggers Puma-induced mitochondr...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Nie, C, Luo, Y, Zhao, X, Luo, N, Tong, A, Liu, X, Yuan, Z, Wang, C, Wei, Y
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649536/
https://ncbi.nlm.nih.gov/pubmed/25356864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.461
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