General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding activity is induced by hypoxia in Hep3B cells, and HIF-1 binds at a site in the EPO gene enhancer that is required for hypoxic...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46495/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8387214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.9.4304 |
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