Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming

The orphan nuclear receptor TLX is a master regulator of postnatal neural stem cell (NSC) self-renewal and neurogenesis; however, it remains unclear how TLX expression is precisely regulated in these tissue-specific stem cells. Here, we show that a highly conserved cis-element within the Tlx locus f...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Islam, Mohammed M., Smith, Derek K., Niu, Wenze, Fang, Sanhua, Iqbal, Nida, Sun, Guoqiang, Shi, Yanhong, Zhang, Chun-Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649261/
https://ncbi.nlm.nih.gov/pubmed/26607952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.09.015
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