SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

Glial cells can be in vivo reprogrammed into functional neurons in the adult CNS; however, the process by which this reprogramming occurs is unclear. Here, we show that a distinct cellular sequence is involved in SOX2-driven in situ conversion of adult astrocytes to neurons. This includes ASCL1(+) n...

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Bibliografske podrobnosti
izdano v:Stem Cell Reports
Main Authors: Niu, Wenze, Zang, Tong, Smith, Derek K., Vue, Tou Yia, Zou, Yuhua, Bachoo, Robert, Johnson, Jane E., Zhang, Chun-Li
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437485/
https://ncbi.nlm.nih.gov/pubmed/25921813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.03.006
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