Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism

Accumulation of α-synuclein (α-syn) into insoluble aggregates occurs in several related disorders collectively referred to as synucleinopathies. To date, studies have used neural stem cells (NSCs) to examine questions about α-syn propagation, but have overlooked the therapeutic potential of NSC tran...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Goldberg, Natalie R.S., Caesar, Jacqueline, Park, Ashley, Sedgh, Shawn, Finogenov, Gilana, Masliah, Eliezer, Davis, Joy, Blurton-Jones, Mathew
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649255/
https://ncbi.nlm.nih.gov/pubmed/26489892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.09.008
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