Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis

AIM: To investigate the mechanisms of insulin resistance in human hepatoma cells expressing hepatitis C virus (HCV) nonstructural protein 5A (NS5A). METHODS: The human hepatoma cell lines, Huh7 and Huh7.5, were infected with HCV or transiently-transfected with a vector expressing HCV NS5A. The effec...

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Bibliografiske detaljer
Udgivet i:World J Gastroenterol
Main Authors: Parvaiz, Fahed, Manzoor, Sobia, Iqbal, Jawed, Sarkar-Dutta, Mehuli, Imran, Muhammad, Waris, Gulam
Format: Artigo
Sprog:Inglês
Udgivet: Baishideng Publishing Group Inc 2015
Fag:
Basic Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649119/
https://ncbi.nlm.nih.gov/pubmed/26604643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i43.12361
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