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Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression

In the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with cyclooxygenase-2 (COX-2) up-regulation. Celecoxib, a selective COX-2 in...

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Autors principals: Liagre, Bertrand, Vergne-Salle, Pascale, Corbiere, Cecile, Charissoux, Jean L, Beneytout, Jean L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC464911/
https://ncbi.nlm.nih.gov/pubmed/15225373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1199
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