Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors

BACKGROUND: Discovery of potent inhibitors of urease (jack bean) enzyme is the first step in the development of drugs against diseases caused by ureolytic enzyme. RESULTS: Thirty-two derivatives of barbituric acid as zwitterionic adducts of diethyl ammonium salts were synthesized. All synthesized co...

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Vydáno v:Chem Cent J
Hlavní autoři: Barakat, Assem, Al-Majid, Abdullah Mohammed, Lotfy, Gehad, Arshad, Fiza, Yousuf, Sammer, Choudhary, M. Iqbal, Ashraf, Sajda, Ul-Haq, Zaheer
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648982/
https://ncbi.nlm.nih.gov/pubmed/26583043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-015-0140-1
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