Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation

Environmental conditions control rRNA transcription. Previously, we found that serum and glucose deprivation induces KDM2A-mediated H3K36me2 demethylation in the rRNA gene (rDNA) promoter and reduces rRNA transcription in the human breast cancer cell line MCF-7. However, the molecular mechanism and...

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Publicado en:Mol Cell Biol
Main Authors: Tanaka, Yuji, Yano, Hirohisa, Ogasawara, Sachiko, Yoshioka, Sho-ichi, Imamura, Hiromi, Okamoto, Kengo, Tsuneoka, Makoto
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648824/
https://ncbi.nlm.nih.gov/pubmed/26416883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00579-15
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