Pathological concentrations of homocysteine increases IL-1β production in macrophages in a P2X7, NF-ĸB, and erk-dependent manner

Elevated plasma levels of homocysteine (Hcy) are associated with the development of coronary artery disease (CAD), peripheral vascular disease, and atherosclerosis. Hyperhomocysteinemia is likely related to the enhanced production of pro-inflammatory cytokines including IL-1β. However, the mechanism...

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Bibliographic Details
Published in:Purinergic Signal
Main Authors: Zanin, Rafael Fernandes, Bergamin, Letícia Scussel, Morrone, Fernanda Bueno, Coutinho-Silva, Robson, de Souza Wyse, Angela Terezinha, Battastini, Ana Maria Oliveira
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648800/
https://ncbi.nlm.nih.gov/pubmed/26265456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-015-9464-5
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