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Pathological concentrations of homocysteine increases IL-1β production in macrophages in a P2X7, NF-ĸB, and erk-dependent manner

Elevated plasma levels of homocysteine (Hcy) are associated with the development of coronary artery disease (CAD), peripheral vascular disease, and atherosclerosis. Hyperhomocysteinemia is likely related to the enhanced production of pro-inflammatory cytokines including IL-1β. However, the mechanism...

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Détails bibliographiques
Publié dans:Purinergic Signal
Auteurs principaux: Zanin, Rafael Fernandes, Bergamin, Letícia Scussel, Morrone, Fernanda Bueno, Coutinho-Silva, Robson, de Souza Wyse, Angela Terezinha, Battastini, Ana Maria Oliveira
Format: Artigo
Langue:Inglês
Publié: Springer Netherlands 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648800/
https://ncbi.nlm.nih.gov/pubmed/26265456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-015-9464-5
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