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Bactericidal antibiotics induce toxic metabolic perturbations that lead to cellular damage

Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (beta-lact...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Belenky, Peter, Ye, Jonathan D., Porter, Caroline B. M., Cohen, Nadia R., Lobritz, Michael A., Ferrante, Thomas, Jain, Saloni, Korry, Benjamin J., Schwarz, Eric G., Walker, Graham C., Collins, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648786/
https://ncbi.nlm.nih.gov/pubmed/26565910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.059
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