Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein

The proteasome is a giant protease responsible for degradation of the majority of cytosolic proteins. Competitive inhibitors of the proteasome are used against aggressive blood cancers. However, broadening the use of proteasome-targeting drugs requires new mechanistic approaches to the enzyme’s inhi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Karpowicz, Przemysław, Osmulski, Paweł A., Witkowska, Julia, Sikorska, Emilia, Giżyńska, Małgorzata, Belczyk-Ciesielska, Agnieszka, Gaczynska, Maria E., Jankowska, Elżbieta
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648528/
https://ncbi.nlm.nih.gov/pubmed/26575189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143038
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