Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma

Liposarcoma (LPS) is a type of soft tissue sarcoma that mostly occurs in adults, and in humans is characterized by amplifications of MDM2 and CDK4. The molecular pathogenesis of this malignancy is still poorly understood and, therefore, we developed a mouse model with conditional inactivation of PTE...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Puzio-Kuter, A M, Laddha, S V, Castillo-Martin, M, Sun, Y, Cordon-Cardo, C, Chan, C S, Levine, A J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648325/
https://ncbi.nlm.nih.gov/pubmed/25822339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.27
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