Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the axonopathy and peroxisomal disease X-linked adrenoleukodystrophy (X-ALD). We ha...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: Morató, L, Ruiz, M, Boada, J, Calingasan, N Y, Galino, J, Guilera, C, Jové, M, Naudí, A, Ferrer, I, Pamplona, R, Serrano, M, Portero-Otín, M, Beal, M F, Fourcade, S, Pujol, A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648322/
https://ncbi.nlm.nih.gov/pubmed/25822341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.20
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