Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common and aggressive form of brain cancer. Our previous studies demonstrated that combined inhibition of HDAC and KDM1A increases apoptotic cell death in vitro. However, whether this combination also increases death of the glioma stem cell (GSC) population...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Singh, Melissa M., Johnson, Blake, Venkatarayan, Avinashnarayan, Flores, Elsa R., Zhang, Jianping, Su, Xiaoping, Barton, Michelle, Lang, Frederick, Chandra, Joya
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648298/
https://ncbi.nlm.nih.gov/pubmed/25795306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov041
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