An unexpected effect of TNF-α on F508del-CFTR maturation and function

Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR), which encodes a cAMP-dependent Cl (-) channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially func...

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Publicado en:F1000Res
Autores principales: Bitam, Sara, Pranke, Iwona, Hollenhorst, Monika, Servel, Nathalie, Moquereau, Christelle, Tondelier, Danielle, Hatton, Aurélie, Urbach, Valérie, Sermet-Gaudelus, Isabelle, Hinzpeter, Alexandre, Edelman, Aleksander
Formato: Artigo
Lenguaje:Inglês
Publicado: F1000Research 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648213/
https://ncbi.nlm.nih.gov/pubmed/26594334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.6683.2
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