Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

BACKGROUND: Positron emission tomography microdosing of radiolabeled drugs allows for noninvasive studies of organ exposure in vivo. The aim of the present study was to examine and compare the brain exposure of 12 commercially available CNS drugs and one non-CNS drug. METHODS: The drugs were radiola...

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Détails bibliographiques
Publié dans:Int J Neuropsychopharmacol
Auteurs principaux: Schou, Magnus, Varnäs, Katarina, Lundquist, Stefan, Nakao, Ryuji, Amini, Nahid, Takano, Akihiro, Finnema, Sjoerd J., Halldin, Christer, Farde, Lars
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648157/
https://ncbi.nlm.nih.gov/pubmed/25813017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyv036
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