Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

To identify the sites in the p53 tumor suppressor gene most susceptible to carcinogenic mutation by sunlight, the entire coding region of 27 basal cell carcinomas (BCCs) of the skin was sequenced. Fifty-six percent of tumors contained mutations, and these were UV-like: primarily CC-->TT or C-->...

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Detalhes bibliográficos
Main Authors: Ziegler, A, Leffell, D J, Kunala, S, Sharma, H W, Gailani, M, Simon, J A, Halperin, A J, Baden, H P, Shapiro, P E, Bale, A E
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46477/
https://ncbi.nlm.nih.gov/pubmed/8483937
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