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Frequent clones of p53-mutated keratinocytes in normal human skin

The multiple genetic hit model of cancer predicts that normal individuals should have stable populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits. We report that whole-mount preparations of human skin contain clonal patches of p53-mutated keratinocytes, arising f...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Jonason, Alan S., Kunala, Subrahmanyam, Price, Gary J., Restifo, Richard J., Spinelli, Henry M., Persing, John A., Leffell, David J., Tarone, Robert E., Brash, Douglas E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences of the USA 1996
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC19488/
https://ncbi.nlm.nih.gov/pubmed/8943054
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