Frequent clones of p53-mutated keratinocytes in normal human skin
The multiple genetic hit model of cancer predicts that normal individuals should have stable populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits. We report that whole-mount preparations of human skin contain clonal patches of p53-mutated keratinocytes, arising f...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19488/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.14025 |
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