Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis

BACKGROUND: Hypoxia leads to the stabilisation of the hypoxia-inducible factor (HIF) transcription factor that drives the expression of target genes including microRNAs (miRNAs). MicroRNAs are known to regulate many genes involved in tumourigenesis. The aim of this study was to identify hypoxia-regu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Blick, C, Ramachandran, A, McCormick, R, Wigfield, S, Cranston, D, Catto, J, Harris, A L
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647685/
https://ncbi.nlm.nih.gov/pubmed/26196183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.203
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