Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Natural killer (NK) cell maturation is a tightly controlled process that endows NK cells with functional competence and the capacity to recognize target cells. Here, we found that the transcription factor (TF) Zeb2 was the most highly induced TF during NK cell maturation. Zeb2 is known to control ep...

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Vydáno v:J Exp Med
Hlavní autoři: van Helden, Mary J., Goossens, Steven, Daussy, Cécile, Mathieu, Anne-Laure, Faure, Fabrice, Marçais, Antoine, Vandamme, Niels, Farla, Natalie, Mayol, Katia, Viel, Sébastien, Degouve, Sophie, Debien, Emilie, Seuntjens, Eve, Conidi, Andrea, Chaix, Julie, Mangeot, Philippe, de Bernard, Simon, Buffat, Laurent, Haigh, Jody J., Huylebroeck, Danny, Lambrecht, Bart N., Berx, Geert, Walzer, Thierry
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647267/
https://ncbi.nlm.nih.gov/pubmed/26503444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150809
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