Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Natural killer (NK) cell maturation is a tightly controlled process that endows NK cells with functional competence and the capacity to recognize target cells. Here, we found that the transcription factor (TF) Zeb2 was the most highly induced TF during NK cell maturation. Zeb2 is known to control ep...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: van Helden, Mary J., Goossens, Steven, Daussy, Cécile, Mathieu, Anne-Laure, Faure, Fabrice, Marçais, Antoine, Vandamme, Niels, Farla, Natalie, Mayol, Katia, Viel, Sébastien, Degouve, Sophie, Debien, Emilie, Seuntjens, Eve, Conidi, Andrea, Chaix, Julie, Mangeot, Philippe, de Bernard, Simon, Buffat, Laurent, Haigh, Jody J., Huylebroeck, Danny, Lambrecht, Bart N., Berx, Geert, Walzer, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647267/
https://ncbi.nlm.nih.gov/pubmed/26503444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150809
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