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MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs
The RNA polymerase II mediator complex subunit 12 (MED12) is frequently mutated in human cancers, and loss of MED12 has been shown to induce drug resistance through activation of transforming growth factor–β receptor (TGF-βR) signaling. We identified MED12 as a substrate for coactivator-associated a...
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| Udgivet i: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Association for the Advancement of Science
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646802/ https://ncbi.nlm.nih.gov/pubmed/26601288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500463 |
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