PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

Metabolic reprogramming is a hallmark of cancer. Herein we discovered that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of m...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Liu, Fabao, Ma, Fengfei, Wang, Yuyuan, Hao, Ling, Zeng, Hao, Jia, Chenxi, Wang, Yidan, Liu, Peng, Ong, Irene M, Li, Baobin, Chen, Guojun, Jiang, Jiaoyang, Gong, Shaoqin, Li, Lingjun, Xu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5683091/
https://ncbi.nlm.nih.gov/pubmed/29058718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3630
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