AKT1 activation promotes the development of melanoma metastases

Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT signaling in human melanoma metastases led us to evaluate the effect of activated AKT1 expression in non-metastatic BRAF(V600E)/Cdkn2a(Null) mouse melanomas in vivo. Expression of activated AKT1 r...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Cho, Joseph H., Robinson, James P., Arave, Rowan A., Burnett, William J., Kircher, David A., Chen, Guo, Davies, Michael A., Grossmann, Allie H., VanBrocklin, Matthew W., McMahon, Martin, Holmen, Sheri L.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646731/
https://ncbi.nlm.nih.gov/pubmed/26565903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.057
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