AKT1 activation promotes the development of melanoma metastases

Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT signaling in human melanoma metastases led us to evaluate the effect of activated AKT1 expression in non-metastatic BRAF(V600E)/Cdkn2a(Null) mouse melanomas in vivo. Expression of activated AKT1 r...

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Publicat a:Cell Rep
Autors principals: Cho, Joseph H., Robinson, James P., Arave, Rowan A., Burnett, William J., Kircher, David A., Chen, Guo, Davies, Michael A., Grossmann, Allie H., VanBrocklin, Matthew W., McMahon, Martin, Holmen, Sheri L.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646731/
https://ncbi.nlm.nih.gov/pubmed/26565903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.057
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