Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability

APOBEC3H is a deoxycytidine deaminase that can restrict the replication of HIV-1 in the absence of the viral protein Vif that induces APOBEC3H degradation in cells. APOBEC3H exists in humans as seven haplotypes (I–VII) with different cellular stabilities. Of the three stable APOBEC3H haplotypes (II,...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Feng, Yuqing, Love, Robin P., Ara, Anjuman, Baig, Tayyba T., Adolph, Madison B., Chelico, Linda
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646388/
https://ncbi.nlm.nih.gov/pubmed/26396192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666065
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