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Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability

APOBEC3H is a deoxycytidine deaminase that can restrict the replication of HIV-1 in the absence of the viral protein Vif that induces APOBEC3H degradation in cells. APOBEC3H exists in humans as seven haplotypes (I–VII) with different cellular stabilities. Of the three stable APOBEC3H haplotypes (II,...

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Vydáno v:J Biol Chem
Hlavní autoři: Feng, Yuqing, Love, Robin P., Ara, Anjuman, Baig, Tayyba T., Adolph, Madison B., Chelico, Linda
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646388/
https://ncbi.nlm.nih.gov/pubmed/26396192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666065
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