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Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability
APOBEC3H is a deoxycytidine deaminase that can restrict the replication of HIV-1 in the absence of the viral protein Vif that induces APOBEC3H degradation in cells. APOBEC3H exists in humans as seven haplotypes (I–VII) with different cellular stabilities. Of the three stable APOBEC3H haplotypes (II,...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646388/ https://ncbi.nlm.nih.gov/pubmed/26396192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666065 |
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