Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (−)-Maackiain Suppresses Histamine H(1) Receptor Gene Transcription in HeLa Cells

The histamine H(1) receptor (H1R) gene is an allergic disease sensitive gene, and its expression level is strongly correlated with the severity of allergic symptoms. (−)-Maackiain was identified as a Kujin-derived anti-allergic compound that suppresses the up-regulation of the H1R gene. However, the...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Nariai, Yuki, Mizuguchi, Hiroyuki, Ogasawara, Takeyasu, Nagai, Hiroaki, Sasaki, Yohei, Okamoto, Yasunobu, Yoshimura, Yoshiyuki, Kitamura, Yoshiaki, Nemoto, Hisao, Takeda, Noriaki, Fukui, Hiroyuki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646370/
https://ncbi.nlm.nih.gov/pubmed/26391399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657023
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