Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (−)-Maackiain Suppresses Histamine H(1) Receptor Gene Transcription in HeLa Cells

The histamine H(1) receptor (H1R) gene is an allergic disease sensitive gene, and its expression level is strongly correlated with the severity of allergic symptoms. (−)-Maackiain was identified as a Kujin-derived anti-allergic compound that suppresses the up-regulation of the H1R gene. However, the...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Nariai, Yuki, Mizuguchi, Hiroyuki, Ogasawara, Takeyasu, Nagai, Hiroaki, Sasaki, Yohei, Okamoto, Yasunobu, Yoshimura, Yoshiyuki, Kitamura, Yoshiaki, Nemoto, Hisao, Takeda, Noriaki, Fukui, Hiroyuki
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2015
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646370/
https://ncbi.nlm.nih.gov/pubmed/26391399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657023
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