Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

Knowledge of the fine location of neutralizing and non-neutralizing epitopes on human pathogens affords a better understanding of the structural basis of antibody efficacy, which will expedite rational design of vaccines, prophylactics, and therapeutics. However, full utilization of the wealth of in...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kowalsky, Caitlin A., Faber, Matthew S., Nath, Aritro, Dann, Hailey E., Kelly, Vince W., Liu, Li, Shanker, Purva, Wagner, Ellen K., Maynard, Jennifer A., Chan, Christina, Whitehead, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646304/
https://ncbi.nlm.nih.gov/pubmed/26296891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676635
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