Evaluation of conformational epitopes on thyroid peroxidase by antipeptide antibody binding and mutagenesis

Autoantibodies to thyroid peroxidase (TPO) recognize predominantly conformational epitopes, which are restricted to two distinct determinants, termed immunodominant domain region (IDR) A and B. These dominant determinants reside in the region with structural homology to myeloperoxidase (MPO)-like do...

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Detalhes bibliográficos
Main Authors: GORA, M, GARDAS, A, WIKTOROWICZ, W, HOBBY, P, WATSON, P F, WEETMAN, A P, SUTTON, B J, BANGA, J P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Clinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809007/
https://ncbi.nlm.nih.gov/pubmed/15030525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02422.x
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