Evaluation of conformational epitopes on thyroid peroxidase by antipeptide antibody binding and mutagenesis

Autoantibodies to thyroid peroxidase (TPO) recognize predominantly conformational epitopes, which are restricted to two distinct determinants, termed immunodominant domain region (IDR) A and B. These dominant determinants reside in the region with structural homology to myeloperoxidase (MPO)-like do...

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Main Authors: GORA, M, GARDAS, A, WIKTOROWICZ, W, HOBBY, P, WATSON, P F, WEETMAN, A P, SUTTON, B J, BANGA, J P
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2004
主題:
Clinical Studies
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809007/
https://ncbi.nlm.nih.gov/pubmed/15030525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02422.x
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