Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption

Islet amyloid polypeptide (IAPP) is a 37-amino acid amyloid protein intimately associated with pancreatic islet β-cell dysfunction and death in type II diabetes. In this study, we combine spectroscopic methods and microscopy to investigate α-helical IAPP-membrane interactions. Using light scattering...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kegulian, Natalie C., Sankhagowit, Shalene, Apostolidou, Melania, Jayasinghe, Sajith A., Malmstadt, Noah, Butler, Peter C., Langen, Ralf
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646232/
https://ncbi.nlm.nih.gov/pubmed/26283787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.659797
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