Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone

Transforming growth factor β1 (TGF-β1) is not only elevated in airways of cystic fibrosis (CF) patients, whose airways are characterized by abnormal ion transport and mucociliary clearance, but TGF-β1 is also associated with worse clinical outcomes. Effective mucociliary clearance depends on adequat...

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Vydáno v:J Biol Chem
Hlavní autoři: Manzanares, Dahis, Krick, Stefanie, Baumlin, Nathalie, Dennis, John S., Tyrrell, Jean, Tarran, Robert, Salathe, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646213/
https://ncbi.nlm.nih.gov/pubmed/26338706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.670885
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