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IFN-γ-mediated reduction of large-conductance, Ca(2+)-activated, voltage-dependent K(+) (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction
Effective mucociliary clearance (MCC) depends in part on adequate airway surface liquid (ASL) volume to maintain an appropriate periciliary fluid height that allows normal ciliary activity. Apically expressed large-conductance, Ca(2+)-activated, and voltage-dependent K(+) (BK) channels provide an el...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949055/ https://ncbi.nlm.nih.gov/pubmed/24414257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00247.2013 |
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