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IFN-γ-mediated reduction of large-conductance, Ca(2+)-activated, voltage-dependent K(+) (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction

Effective mucociliary clearance (MCC) depends in part on adequate airway surface liquid (ASL) volume to maintain an appropriate periciliary fluid height that allows normal ciliary activity. Apically expressed large-conductance, Ca(2+)-activated, and voltage-dependent K(+) (BK) channels provide an el...

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書誌詳細
主要な著者: Manzanares, Dahis, Srinivasan, Maria, Salathe, Samuel T., Ivonnet, Pedro, Baumlin, Nathalie, Dennis, John S., Conner, Gregory E., Salathe, Matthias
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949055/
https://ncbi.nlm.nih.gov/pubmed/24414257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00247.2013
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