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IFN-γ-mediated reduction of large-conductance, Ca(2+)-activated, voltage-dependent K(+) (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction

Effective mucociliary clearance (MCC) depends in part on adequate airway surface liquid (ASL) volume to maintain an appropriate periciliary fluid height that allows normal ciliary activity. Apically expressed large-conductance, Ca(2+)-activated, and voltage-dependent K(+) (BK) channels provide an el...

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Bibliografske podrobnosti
Main Authors: Manzanares, Dahis, Srinivasan, Maria, Salathe, Samuel T., Ivonnet, Pedro, Baumlin, Nathalie, Dennis, John S., Conner, Gregory E., Salathe, Matthias
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949055/
https://ncbi.nlm.nih.gov/pubmed/24414257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00247.2013
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