Roflumilast partially reverses smoke-induced mucociliary dysfunction

BACKGROUND: Phosphodiesterases (PDEs) break down cAMP, thereby regulating intracellular cAMP concentrations and diffusion. Since PDE4 predominates in airway epithelial cells, PDE4 inhibitors can stimulate Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by increasing cAMP. Tobacco smoking...

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Bibliografische gegevens
Gepubliceerd in:Respir Res
Hoofdauteurs: Schmid, Andreas, Baumlin, Nathalie, Ivonnet, Pedro, Dennis, John S., Campos, Michael, Krick, Stefanie, Salathe, Matthias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628339/
https://ncbi.nlm.nih.gov/pubmed/26521141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0294-3
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