Roflumilast partially reverses smoke-induced mucociliary dysfunction

BACKGROUND: Phosphodiesterases (PDEs) break down cAMP, thereby regulating intracellular cAMP concentrations and diffusion. Since PDE4 predominates in airway epithelial cells, PDE4 inhibitors can stimulate Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by increasing cAMP. Tobacco smoking...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Respir Res
Main Authors: Schmid, Andreas, Baumlin, Nathalie, Ivonnet, Pedro, Dennis, John S., Campos, Michael, Krick, Stefanie, Salathe, Matthias
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628339/
https://ncbi.nlm.nih.gov/pubmed/26521141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0294-3
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