Small Retinoprotective Peptides Reveal a Receptor-binding Region on Pigment Epithelium-derived Factor

The cytoprotective effects of pigment epithelium-derived factor (PEDF) require interactions between an as of a yet undefined region with a distinct ectodomain on the PEDF receptor (PEDF-R). Here we characterized the area in PEDF that interacts with PEDF-R to promote photoreceptor survival. Molecular...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kenealey, Jason, Subramanian, Preeti, Comitato, Antonella, Bullock, Jeanee, Keehan, Laura, Polato, Federica, Hoover, David, Marigo, Valeria, Becerra, S. Patricia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646175/
https://ncbi.nlm.nih.gov/pubmed/26304116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645846
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