Histone deacetylase inhibitor‐mediated cell death is distinct from its global effect on chromatin

Romidepsin and vorinostat are histone deacetylase inhibitors (HDACis) that have activity in T‐cell lymphomas, but have not gained traction in solid tumors. To gain deeper insight into mechanisms of HDACi efficacy, we systematically surveyed 19 cell lines with different molecular phenotypes, comparin...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Luchenko, Victoria L., Litman, Thomas, Chakraborty, Arup R., Heffner, Aaron, Devor, Christopher, Wilkerson, Julia, Stein, Wilfred, Robey, Robert W., Bangiolo, Lois, Levens, David, Bates, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646083/
https://ncbi.nlm.nih.gov/pubmed/24954856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.05.001
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