MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

To identify molecular determinants of histone deacetylase inhibitor (HDI) resistance, we selected HuT78 cutaneous T-cell lymphoma (CTCL) cells with romidepsin in the presence of P-glycoprotein inhibitors to prevent transporter upregulation. Resistant sublines were 250- to 385-fold resistant to romid...

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Bibliografische gegevens
Hoofdauteurs: Chakraborty, Arup R., Robey, Robert W., Luchenko, Victoria L., Zhan, Zhirong, Piekarz, Richard L., Gillet, Jean-Pierre, Kossenkov, Andrew V., Wilkerson, Julia, Showe, Louise C., Gottesman, Michael M., Collie, Nathan L., Bates, Susan E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2013
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656450/
https://ncbi.nlm.nih.gov/pubmed/23532732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449140
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