Modification of Asparagine-Linked Glycan Density for the Design of Hepatitis B Virus Virus-Like Particles with Enhanced Immunogenicity

The small envelope proteins (HBsAgS) derived from hepatitis B virus (HBV) represent the antigenic components of the HBV vaccine and are platforms for the delivery of foreign antigenic sequences. To investigate structure-immunogenicity relationships for the design of improved immunization vectors, we...

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Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Hyakumura, Michiko, Walsh, Renae, Thaysen-Andersen, Morten, Kingston, Natalie J., La, Mylinh, Lu, Louis, Lovrecz, George, Packer, Nicolle H., Locarnini, Stephen, Netter, Hans J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2015
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645671/
https://ncbi.nlm.nih.gov/pubmed/26339047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01123-15
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