Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function

HLA-B*13 is associated with superior in vivo HIV-1 viremia control. Protection is thought to be mediated by sustained targeting of key cytotoxic T lymphocyte (CTL) epitopes and viral fitness costs of CTL escape in Gag although additional factors may contribute. We assessed the impact of 10 published...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Shahid, Aniqa, Olvera, Alex, Anmole, Gursev, Kuang, Xiaomei T., Cotton, Laura A., Plana, Montserrat, Brander, Christian, Brockman, Mark A., Brumme, Zabrina L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Cellular Response to Infection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645636/
https://ncbi.nlm.nih.gov/pubmed/26355081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01955-15
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