Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

Many viruses affect or exploit the phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway, a crucial prosurvival signaling cascade. We report that this pathway was strongly activated in cells upon infection with the Old World alphavirus Semliki Forest virus (SFV), even...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Thaa, Bastian, Biasiotto, Roberta, Eng, Kai, Neuvonen, Maarit, Götte, Benjamin, Rheinemann, Lara, Mutso, Margit, Utt, Age, Varghese, Finny, Balistreri, Giuseppe, Merits, Andres, Ahola, Tero, McInerney, Gerald M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645633/
https://ncbi.nlm.nih.gov/pubmed/26339054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01579-15
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