Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling

Congenital insensitivity to pain (CIP) or congenital analgesia is a rare monogenic hereditary condition. This disorder is characterized by the inability to perceive any form of pain. Nonsense mutations in Nav.1.7, the main pain signaling voltage-gated sodium channel, lead to its truncations and, con...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Remacle, Albert G., Kumar, Sonu, Motamedchaboki, Khatereh, Cieplak, Piotr, Hullugundi, Swathi, Dolkas, Jennifer, Shubayev, Veronica I., Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645627/
https://ncbi.nlm.nih.gov/pubmed/26283785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C115.671107
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