Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression

Aberrant deposition of fat including free fatty acids in the liver often causes damage to hepatocytes, namely lipotoxicity, which is a key pathogenic event in the development and progression of fatty liver diseases. This study demonstrates a pivotal role of sphingosine kinase 1 (SphK1) in protecting...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Qi, Yanfei, Wang, Wei, Chen, Jinbiao, Dai, Lan, Kaczorowski, Dominik, Gao, Xin, Xia, Pu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645625/
https://ncbi.nlm.nih.gov/pubmed/26240153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677542
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