Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages

Interferon (IFN)-inducible guanylate binding proteins (GBPs) mediate cell-autonomous host resistance to bacterial pathogens and promote inflammasome activation. The prevailing model postulates that these two GBP-controlled activities are directly linked through GBP-dependent vacuolar lysis. It was p...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Finethy, Ryan, Jorgensen, Ine, Haldar, Arun K., de Zoete, Marcel R., Strowig, Till, Flavell, Richard A., Yamamoto, Masahiro, Nagarajan, Uma M., Miao, Edward A., Coers, Jörn
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645370/
https://ncbi.nlm.nih.gov/pubmed/26416908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00856-15
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