Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune response linked to sepsis. Host guanylate binding proteins (GBPs) promote infect...

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Vydáno v:mBio
Hlavní autoři: Finethy, Ryan, Luoma, Sarah, Orench-Rivera, Nichole, Feeley, Eric M., Haldar, Arun K., Yamamoto, Masahiro, Kanneganti, Thirumala-Devi, Kuehn, Meta J., Coers, Jörn
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626967/
https://ncbi.nlm.nih.gov/pubmed/28974614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01188-17
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