Vaccine-Derived Neutralizing Antibodies to the Human Cytomegalovirus gH/gL Pentamer Potently Block Primary Cytotrophoblast Infection

Human cytomegalovirus (HCMV) elicits neutralizing antibodies (NAb) of various potencies and cell type specificities to prevent HCMV entry into fibroblasts (FB) and epithelial/endothelial cells (EpC/EnC). NAb targeting the major essential envelope glycoprotein complexes gB and gH/gL inhibit both FB a...

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Publicado en:J Virol
Autores principales: Chiuppesi, Flavia, Wussow, Felix, Johnson, Erica, Bian, Chao, Zhuo, Meng, Rajakumar, Augustine, Barry, Peter A., Britt, William J., Chakraborty, Rana, Diamond, Don J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645301/
https://ncbi.nlm.nih.gov/pubmed/26378171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01701-15
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