Discovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides

[Image: see text] A series of novel N-acyclic uracil analogs with linear, branched, aromatic, and cyclopropyl-alkynyl as well as heteroaryl moieties at C-5 were prepared using palladium catalyzed Sonogashira and Stille cross-coupling and evaluated against malignant tumor cell lines. C-5-Furan-2-yl u...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Meščić, Andrijana, Harej, Anja, Klobučar, Marko, Glavač, Danijel, Cetina, Mario, Pavelić, Sandra Kraljević, Raić-Malić, Silvana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2015
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645252/
https://ncbi.nlm.nih.gov/pubmed/26617970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00298
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